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  • Title: The role of surgical biopsy in the diagnosis of glioma in individuals with neurofibromatosis-1.
    Author: Leonard JR, Perry A, Rubin JB, King AA, Chicoine MR, Gutmann DH.
    Journal: Neurology; 2006 Oct 24; 67(8):1509-12. PubMed ID: 17060590.
    Abstract:
    Most gliomas in neurofibromatosis type 1 (NF1) are pilocytic astrocytomas (PAs) of the optic pathway occurring in young children. However, some individuals develop gliomas that lack the typical NF1-associated clinical features or radiographic appearance. We identified 17 atypical presentations from a review of 100 patients with NF1-associated gliomas. Biopsy showed that 9 were not classic PAs. These data highlight the value of biopsy in NF1-associated gliomas with unusual clinical or radiographic presentations.
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