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  • Title: Treatment of mediastinal immature teratoma in a child with precocious puberty and Klinefelter's syndrome.
    Author: Chen CK, Chang YL, Jou ST, Tseng YT, Lee YC.
    Journal: Ann Thorac Surg; 2006 Nov; 82(5):1906-8. PubMed ID: 17062277.
    Abstract:
    Teratoma is the most common germ cell tumor, which can be divided into the mature and the immature histologically. Concurrent Klinefelter's syndrome may be overlooked in a patient with a germ cell tumor. This is because the tumor that secrets alpha-fetoprotein and beta human chorionic gonadotropin can mimic puberty in a patient with Klinefelter's syndrome, masking the usual clinical signs. In reviewing the literature on the subject, the role of neoadjuvant and adjuvant chemotherapy remains ill-defined for the immature teratoma. Age-dependent prognosis seems to demonstrate that children with immature teratomas have a better outcome. We share the experience of treating a child with immature teratoma with surgical excision alone, and it ended in a local recurrence.
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