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  • Title: [Association of abnormal cyclooxygenase-2 gene expression with colorectal carcinoma metastasis].
    Author: Li ZG, Liu TF, Xie WB, Zhou J, Yu L, Ding YQ.
    Journal: Nan Fang Yi Ke Da Xue Xue Bao; 2006 Oct; 26(10):1408-11. PubMed ID: 17062337.
    Abstract:
    OBJECTIVE: To investigate cyclooxygenase-2 (COX-2) expression of in colorectal carcinoma cell lines and tissues and its clinical implications. METHODS: SP immunohistochemistry was used to detect COX-2 protein in SW480 and SW620 cell lines and 50 primary colorectal carcinoma and 50 lymphoma metastasis carcinoma specimens. Real-time PCR was used to detect COX-2 mRNA expression in SW480 and SW620 cell lines. RESULTS: SW480 and SW620 cell lines both highly expressed COX-2. The positive expression levels of COX-2 increased significantly in lymph node metastatic carcinoma in comparison with primary colorectal carcinoma (P<0.05). The expression COX-2 mRNA in SW620 cell line was higher than that of SW480 cell line, showing a mean expression increment of 2.268 folds in SW620 cell line relative to SW480. CONCLUSION: Elevated COX-2 expression may be associated with lymph node metastases of colorectal carcinoma.
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