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  • Title: [Inhibitory effect of reinioside C on LOX-1 expression induced by ox-LDL].
    Author: Bai YP, Zhang GG, Shi RZ, Li YJ, Tan GS, Chen J.
    Journal: Zhong Nan Da Xue Xue Bao Yi Xue Ban; 2006 Oct; 31(5):659-62. PubMed ID: 17062925.
    Abstract:
    OBJECTIVE: To investigate the effect of reinioside C (RC) on the expression of lectin-like oxidized low density lipoprotein receptor (LOX)-1 mRNA and LOX-1 protein induced by oxidized low density lipoprotein (ox-LDL) in cultured human umbilical vein endothelial cells (HUVEC). METHODS: HUVECs were cultured with ox-LDL (50 mg/L) for 24 h in the absence or presence of RC (1, 3, and 10 micromol/L). The expressions of LOX-1 mRNA and LOX-1 protein were examined by RT-PCR and Western-blot. RESULTS: Incubation with ox-LDL (50 mg/L) significantly raised the expression of LOX-1 mRNA and LOX-1 protein,which was concentration-dependent. CONCLUSION: RC can inhibit the increased expression of LOX-1 mRNA and LOX-1 protein induced by ox-LDL in HUVECs.
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