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  • Title: Detection of herpes simplex virus type 1 DNA in bilateral human trigeminal ganglia and optic nerves by polymerase chain reaction.
    Author: Motani H, Sakurada K, Ikegaya H, Akutsu T, Hayakawa M, Sato Y, Yajima D, Sato K, Kobayashi K, Iwase H.
    Journal: J Med Virol; 2006 Dec; 78(12):1584-7. PubMed ID: 17063515.
    Abstract:
    Herpes simplex virus type 1 (HSV-1) DNA was extracted from human trigeminal ganglia of 121 cadavers aged between 3 months and 94 years, and its PCR amplification was performed for the RL2 HSV-1 sequence using two pairs of primers. The HSV-1 DNA was detected in 74 of 121 patients (61%); 70/74 bilaterally, 3/74 only on the left side, and 1/74 only on the right side. Although the PCR-positive rate was significantly higher in advanced age, the correlation between the PCR-positive rate and gender was unclear. Additionally, HSV-1 DNA was not detected in any of the 50 optic nerve samples.
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