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  • Title: Synthesis and antidiabetic activity of novel 2,4-thiazolidinedione derivatives containing a thiazole ring.
    Author: Bozdağ-Dündar O, Ceylan-Unlüsoy M, Verspohl EJ, Ertan R.
    Journal: Arzneimittelforschung; 2006; 56(9):621-5. PubMed ID: 17063636.
    Abstract:
    A series of thiazolyl-2,4-thiazolidinediones (Ia-f, IIa-f and IIIa-f) was prepared by Knoevenagel reaction of substituted benzyl-2,4-thiazolidinediones (4a-f) with chlorothiazolecarbaldehydes (2, 3a-b). The prepared compounds were tested for their insulinotropic activities in INS-1 cells. A significant insulinotropic effect was seen with compounds If and IIa.
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