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  • Title: Dynasore puts a new spin on dynamin: a surprising dual role during vesicle formation.
    Author: Nankoe SR, Sever S.
    Journal: Trends Cell Biol; 2006 Dec; 16(12):607-9. PubMed ID: 17064900.
    Abstract:
    During clathrin-mediated endocytosis, dynamin promotes the formation of clathrin-coated vesicles, but its mode of action is unresolved. In a recent study, Macia and colleagues made use of dynasore, a dynamin-specific inhibitor, to show that dynamin plays a dual role in endocytosis: they confirmed that dynamin is involved in detaching fully formed coated pits from the membrane, and also propose a new role for dynamin earlier in the process at the point of invagination.
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