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  • Title: Clostridium perfringens antigens recognized by broiler chickens immune to necrotic enteritis.
    Author: Kulkarni RR, Parreira VR, Sharif S, Prescott JF.
    Journal: Clin Vaccine Immunol; 2006 Dec; 13(12):1358-62. PubMed ID: 17065258.
    Abstract:
    Little is known about immunity to necrotic enteritis (NE) in chickens. A recent study of broiler chickens showed that protection against NE was associated with infection-immunization with virulent but not with avirulent Clostridium perfringens. In the current study, six secreted antigenic proteins unique to virulent C. perfringens that reacted to serum antibodies from immune birds were identified by mass spectrophotometry; three of these proteins are part of the VirR-VirS regulon.
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