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  • Title: The effect of cyclosporine on exocrine function of the rat pancreas--an in vitro study.
    Author: López-Miranda J, Blanco-Molina A, López-Segura F, Nicolás-Puiggari M, Torre-Cisneros J, Pérez-Jiménez F.
    Journal: Transplantation; 1991 Mar; 51(3):562-5. PubMed ID: 1706541.
    Abstract:
    We have studied the effect of cyclosporine on the exocrine pancreas of rats submitted to treatment with different parenteral doses (15, 30, 50 mg/kg/day) for different time periods (7 and 30 days). Serum amylase levels, pancreas weight, and total pancreatic amylase and protein content showed a dose-dependent decrease. Basal amylase secretion from isolated lobules remained unchanged. Furthermore, the pancreatic lobules from animals under cyclosporine treatment exhibited a decreased response to bethanechol stimulation. Our data suggest that cyclosporine produces a toxic effect on exocrine pancreatic function.
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