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  • Title: [The relationship between expression of interleukin-8 and prognosis of breast cancer].
    Author: Yao C, Wang SM, Xie D, Wu HX, Chen DY, Lin Y.
    Journal: Zhonghua Wai Ke Za Zhi; 2006 Jul 01; 44(13):900-3. PubMed ID: 17067482.
    Abstract:
    OBJECTIVE: To investigate the expression of interleukin-8 (IL-8) and its prognostic significance in breast cancer. METHODS: Expression of IL-8 in 113 breast cancers, 19 breast benign tumors and 20 breast normal tissues was examined by tissue microarray using immunohistochemistry, and the association of IL-8 expression with patient's clinico-pathological characteristics and prognosis was further analyzed. RESULTS: The positive rate of IL-8 expression in breast cancer was 27.4%, which was significantly higher than that in benign tumor and normal tissue of breast (P = 0.002). IL-8 expression related to histological type (P = 0.040) and lymph node status (P = 0.021). The expression of IL-8 was observed to correlate negatively with ER and PR status (P = 0.015 and P = 0.034), and correlate positively with C-erbB-2 status (P = 0.002). In addition, Kaplan-Meier curves of disease-free survival analysis showed a significant difference between IL-8 positive groups and negative group (P = 0.031). CONCLUSIONS: IL-8 might be a poor prognostic factor for human breast cancer, and also might be a novel molecular marker to predicate the occurrence and progression of breast cancer.
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