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  • Title: Toxoplasmic chorioretinitis and antitumor necrosis factor treatment in rheumatoid arthritis.
    Author: Lassoued S, Zabraniecki L, Marin F, Billey T.
    Journal: Semin Arthritis Rheum; 2007 Feb; 36(4):262-3. PubMed ID: 17067660.
    Abstract:
    OBJECTIVES: To present the data supporting the possible relationship of ocular toxoplasmosis to antitumor necrosis factor-alpha (TNF-alpha) therapy in patients with rheumatoid arthritis (RA). METHODS: A Medline search was performed using the words "toxoplasmosis, anti-TNF-alpha antagonists, chorioretinitis." We report 2 RA patients who developed ocular toxoplasmosis while receiving anti-TNF-alpha therapy. RESULTS: In addition to our patients with toxoplasmic chorioretinitis, there are 2 published cases of cerebral toxoplasmosis during treatment with anti-TNF-alpha agents. CONCLUSION: The risk of serious toxoplasmic infection during anti-TNF-alpha therapy for RA should be recognized.
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