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  • Title: Increased urinary excretion of cyclic guanosine monophosphate in rats bearing Morris hepatoma 3924A.
    Author: Murad F, Kimura H, Hopkins HA, Looney WB, Kovacs CJ.
    Journal: Science; 1975 Oct 03; 190(4209):58-60. PubMed ID: 170677.
    Abstract:
    Urinary excretion of cyclic guanosine monophosphate (GMP) increased in rats bearing Morris hepatoma 3924A, and a correlation coefficient of .842 was observed comparing nucleotide excretion and tumor size. Irradiation of tumor or 5-fluorouracil administration delayed the increases in urinary cyclic GMP and tumor size. Surgical removal of tumors resulted in a rapid decline in cyclic GMP excretion to baseline levels. Cyclic adenosine monophosphate excretion was not altered by implantation, irradiation, or excision of tumor.
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