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  • Title: Human chorionic gonadotropin, its free subunits and gestational trophoblastic disease.
    Author: Ozturk M.
    Journal: J Reprod Med; 1991 Jan; 36(1):21-6. PubMed ID: 1706779.
    Abstract:
    Monoclonal antibody-based immunoassays can detect specifically intact human chorionic gonadotropin (hCG), the free alpha-subunit and the free beta-subunit. The differential production of hCG and its free subunits is important in gestational trophoblastic disease. Using well-defined epitope-specific monoclonal antibodies in an immunoradiometric assay format, specific and sensitive assays have been developed. Serum levels of free beta-hCG were abnormally high in patients with gestational trophoblastic disease. In contrast, free alpha-hCG levels in serum were not increased.
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