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  • Title: Quantitative imaging of Plasmodium sporozoites in the mammalian host.
    Author: Amino R, Thiberge S, Shorte S, Frischknecht F, Ménard R.
    Journal: C R Biol; 2006 Nov; 329(11):858-62. PubMed ID: 17067928.
    Abstract:
    Malaria, the disease caused by Plasmodium, kills more than 1 million people annually. Little is known of the pre-erythrocytic phase of the parasite life cycle, i.e., after the sporozoite stage is inoculated in the dermis by a mosquito and before the erythrocyte-infecting stage is released from hepatocytes. We present here a quantitative, real-time analysis of the fate of parasites transmitted in a rodent system. We describe previously unrecognized steps in the parasite's journey to the liver of the host, which are likely to play an important role in the host immune response.
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