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  • Title: [Clinicopathologic manifestation of amiodarone-induced lung injury].
    Author: Shi JH, Liu HR, Zhu YJ, Xu WB.
    Journal: Zhonghua Bing Li Xue Za Zhi; 2006 Jul; 35(7):394-7. PubMed ID: 17069673.
    Abstract:
    OBJECTIVE: To study the clinical, pathologic and radiologic features of amiodarone-induced lung injury. METHODS: The clinical, pathologic and radiologic features, including treatment and follow-up information of three cases diagnosed as amiodarone-induced lung injury from October 2004 to October 2005 in the Peking Union Medical College Hospital were reviewed. RESULTS: All the patients were males, with age ranging from 35 to 64 years. The duration of symptoms varied from 20 days to 3 years. All presented with cough. Worsening dyspnea and inspiratory crackles were noted in two patients. Computerized tomography showed bilateral patchy infiltration, ground-glass appearance and accentuation of bronchovascular markings. The most common pathologic manifestations included cellular interstitial pneumonia associated with intra-alveolar collections of macrophages and type II pneumocyte hyperplasia. Some of the macrophages contained finely vacuolated cytoplasm. An organizing pneumonia pattern was seen in one patient. CONCLUSIONS: Amiodarone-induced lung injury has characteristic pathologic features which may provide clues to diagnosis. Correlation with clinical and radiologic findings is also important.
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