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  • Title: Idiopathic intracranial hypertension and transverse sinus stenosis: a modelling study.
    Author: Stevens SA, Previte M, Lakin WD, Thakore NJ, Penar PL, Hamschin B.
    Journal: Math Med Biol; 2007 Mar; 24(1):85-109. PubMed ID: 17071863.
    Abstract:
    Idiopathic intracranial hypertension (IIH) is a syndrome of unknown etiology characterized by elevated intracranial pressure (ICP). Although a stenosis of the transverse sinus has been observed in many IIH patients, the role this feature plays in IIH is in dispute. In this paper, a lumped-parameter model is developed for the purpose of analytically investigating the elevated pressures associated with IIH and a collapsible transverse sinus. This analysis yields practical predictions regarding the degree of elevated ICPs and the effectiveness of various treatment methods. Results suggest that IIH may be caused by a sufficiently collapsible transverse sinus, but it is also possible that a stenosed sinus may persist following resolution of significant intracranial hypertension.
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