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  • Title: [Production of virus-induced and mitogen-induced interferons by canine cells].
    Author: Georgadze II, Orlova TG, Topuriia NV, Agladze MG, Togoshvili RG.
    Journal: Vopr Virusol; 1990; 35(6):486-8. PubMed ID: 1707197.
    Abstract:
    Cells of monocytic-phagocytic series and immunocompetent cells derived from dogs: bone marrow, leukocytes, spleen, thymus, lymph nodes (with the exception of the liver) were found to be capable of producing interferon (IFn) in vitro in response to inoculation of viral and non-viral inducers. This capacity is manifested in different ways: thymus and lymph node cells were less active interferon producers. Studies of physicochemical properties of the resulting interferons confirmed the belonging of the virus-induced IFn to alpha-interferons, PHA-induced IFn to immune alpha-IFn. The above-mentioned refers both to bone marrow and leukocyte interferons.
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