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  • Title: Large cell neuroendocrine carcinoma of the ampulla of vater: Report of a case.
    Author: Huang SS, Jan YJ, Cheng SB, Yeh DC, Wu CC, Liu TJ, P'eng FK.
    Journal: Surg Today; 2006; 36(11):1032-5. PubMed ID: 17072731.
    Abstract:
    Large cell neuroendocrine carcinoma in the ampulla of Vater is rare and very different from the common ampullary adenocarcinoma. A 59-year-old man was admitted with obstructive jaundice. Gastroendoscopy showed a swollen ampulla of Vater and pathological examination of an ampullary biopsy revealed findings of a carcinoid tumor. After endoscopic biliary drainage, he underwent pancreaticoduodenectomy. A diagnosis of large cell neuroendocrine carcinoma was confirmed by immunohistochemical examination of the resected specimen. Despite adjuvant chemotherapy with cyclophosphamide and cisplatin, liver and peritoneal metastasis developed within 5 months and he survived for only 10 months after the operation. Thus, further investigations are needed to find a more effective postoperative adjuvant chemotherapy agent to treat patients with this aggressive tumor.
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