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  • Title: Changes in the fine structure and function of a hormone-secreting adrenocortical tumour investigated in tissue culture.
    Author: Szabó D, Gyévai A, Gláz E, Stark E, Péteri M, Alánt O.
    Journal: Virchows Arch A Pathol Anat Histol; 1975 Sep 18; 367(4):273-80. PubMed ID: 170731.
    Abstract:
    Tissue cultures of a surgically removed adrenocortical tumour causing Cushing's syndrome, and tissue cultures from the attached, tumour-free adrenal were studied. There were two cell types characteristic of tumour tissue. The cell type occurring most frequently had pronounced hypertrophied agranular endoplasmic reticulum. A fewer number of lipid-rich cells containing many electron-dense granules could also be found. The ratio of cells changed during cultivation. In the 17 days tumour culture, a higher percentage of lipid-rich cells could be observed. In spite of continuous ACTH treatment, the initially high hydrocortisone level decreased, gradually. It may be assumed that the lipid-rich cells are of reduced ability as regards hydrocortisone production.
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