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  • Title: Distribution of cytoplasmic vacuoles in blood T and B lymphocytes in two lysosomal disorders.
    Author: Aula P, Rapola J, Andersson LC.
    Journal: Virchows Arch B Cell Pathol; 1975 Sep 11; 18(4):263-71. PubMed ID: 170734.
    Abstract:
    Distribution of cytoplasmic vacuoles in purified T and B lymphocytes was analyzed in four cases of aspartylglucosaminuria (AGU) and in one case of neuronal ceroid lipofuscinosis (Spielmeyer-Sjörgren type). In all cases T cells were significantly more vacuolized than B cells. The ultrastructure of the cytoplasmic vacuoles was consistent with the concept of storage lysosomes. The cytoplasmic vacuoles both in T and B cells similar to abnormal lysosomes seen in the visceral organs in these diseases.
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