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  • Title: Methods and protocols for prediction of immunogenic epitopes.
    Author: Tong JC, Tan TW, Ranganathan S.
    Journal: Brief Bioinform; 2007 Mar; 8(2):96-108. PubMed ID: 17077136.
    Abstract:
    T-cell recognition of peptide/major histocompatibility complex (MHC) is a prerequisite for cellular immunity. Recently, there has been an influx of bioinformatics tools to facilitate the identification of T-cell epitopes to specific MHC alleles. This article examines existing computational strategies for the study of peptide/MHC interactions. The most important bioinformatics tools and methods with relevance to the study of peptide/MHC interactions have been reviewed. We have also provided guidelines for predicting antigenic peptides based on the availability of existing experimental data.
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