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  • Title: Identification of epitopes within the circumsporozoite protein of Plasmodium vivax recognized by murine T lymphocytes.
    Author: Rodrigues MM, Paiva AC, Dutra AP, Yoshida N, Nakaie C.
    Journal: Exp Parasitol; 1991 Apr; 72(3):271-7. PubMed ID: 1707825.
    Abstract:
    The murine cellular immune response to the circumsporozoite (CS) protein of Plasmodium vivax was characterized using five synthetic peptides, some of which we identified as corresponding to T cell epitopes. The peptides P308-320, P344-355 and P353-364 were immunogenic, inducing a genetically restricted proliferative response, due to the activation of CD4+ T cells. The peptide P308-320 was recognized only by the lymphocytes of B10 (H-2b) mice. The other two peptides were recognized by primed lymphocytes of H-2a and H-2k mice. Of interest was the finding that one of these peptides, P353-364, induced a proliferative response of a large percentage of immune outbred Swiss mice. Our data provide evidence that, at least in mice, there is recognition of multiple T cell epitopes within the major surface antigen of P. vivax sporozoites.
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