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  • Title: In vitro assays show a dissociation of reverse transcriptase activity and core antigen (p24) production in two HIV-1 isolates from a patient receiving long-term treatment with zidovudine (ZDV).
    Author: Masquelier B, Combeau T, Poveda JD, Delord B, Pellegrin JL, Sallafranque-Andreola ML, Tarrago-Litvak L, Fleury HJ.
    Journal: J Acquir Immune Defic Syndr (1988); 1991; 4(5):499-505. PubMed ID: 1707962.
    Abstract:
    Two HIV-1 isolates were obtained from a patient receiving long-term treatment with zidovudine (ZDV). The in vitro sensitivity to ZDV triphosphate of the reverse transcriptase (RT) from both isolates appeared to be unchanged compared to that of the LAV-Bru HIV-1 reference strain. When isolates were grown in CEM cells (a T-lymphoblastoid tumor cell line) and their RT activity and core antigen (p24) production were determined, the level of p24 production compared to RT activity was high; in infected CEM cells treated with ZDV, RT activity was at background level while the p24 production was still significant, thus indicating a dissociation of RT activity and core antigen production.
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