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  • Title: A cluster of nosocomial herpes simplex virus type 1 pneumonia in a medical intensive care unit.
    Author: Mohan S, Hamid NS, Cunha BA.
    Journal: Infect Control Hosp Epidemiol; 2006 Nov; 27(11):1255-7. PubMed ID: 17080387.
    Abstract:
    We report a cluster of 3 cases of nosocomial herpes simplex virus type 1 (HSV-1) pneumonia occurring in close temporal and physical proximity during a 1-week period, which suggested a common source. HSV-1 nosocomial pneumonia occurs in immunocompetent intubated patients and presents as otherwise unexplained profound and/or prolonged hypoxemia (decreased F(IO2), increased P(O2), and decreased A-a gradient) and "failure to wean." The diagnosis of HSV-1 pneumonia is determined by demonstration of characteristic cytopathologic findings (Cowdry type A inclusion bodies) in distal respiratory epithelial cells from bronchoscopic specimens. Acyclovir therapy results in rapid improvement and ability to wean.
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