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  • Title: [Development of a gas chromatography-mass spectrometry method for the quantification of propofol in blood].
    Author: Zhu YJ, Ding XK.
    Journal: Fa Yi Xue Za Zhi; 2006 Aug 15; 22(4):313-4. PubMed ID: 17080679.
    Abstract:
    OBJECTIVE: A rapid and selective method has been developed for the determination of propofol in blood by gas chromatography-mass spectrometry (GC-MS). METHODS: The blood was extrasted with the solution of internal standard, the extracted residue was analyzed by gas chromatography-mass spectrometry using selected-ion monitoring mode. RESULTS: The linear range was 0.1-10 microg/mL. The coefficient(R2) was 0.993 1. The detection limit was 0.05 microg/mL. CONCLUSION: The method is simple and rapid, offering superior sensitivity and selectivity for propofol. The method can be used successfully during clinical and forensic toxicology.
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