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  • Title: Cylindrocyclin A, a new cytotoxic cyclopeptide from Cylindrocarpon sp.
    Author: Weber D, Erosa G, Sterner O, Anke T.
    Journal: J Antibiot (Tokyo); 2006 Aug; 59(8):495-9. PubMed ID: 17080686.
    Abstract:
    In the course of a screening of fungal extracts for new metabolites with cytotoxic activities cylindrocyclin A (1) was isolated. The producing strain was identified as Cylindrocarpon sp. by microscopy and ITS rDNA sequence analysis. 1 is a novel compound that exhibits cytotoxic acticity against six different cell lines with IC50 values ranging from 11 to 53 microM. 1 has no antibacterial or antifungal activity. The compound is a cyclic nonapeptide comprising three alanines, five leucines and one isoleucine. Four amino acids are N-methylated. Its structure was elucidated by spectroscopic methods.
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