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  • Title: Relationship between endometrial thickness and embryo implantation, based on 1,294 cycles of in vitro fertilization with transfer of two blastocyst-stage embryos.
    Author: Richter KS, Bugge KR, Bromer JG, Levy MJ.
    Journal: Fertil Steril; 2007 Jan; 87(1):53-9. PubMed ID: 17081537.
    Abstract:
    OBJECTIVE: To evaluate the relationship between endometrial thickness and clinical outcome of IVF and ET. DESIGN: Retrospective study. SETTING: Private assisted reproductive technology center. PATIENTS: One thousand two hundred and ninety-four infertility patients. INTERVENTIONS: IVF and fresh autologous ET of two blastocyst-stage embryos, including at least one good-quality blastocyst. MAIN OUTCOME MEASURES: Clinical pregnancy rate (PR) and spontaneous abortion rate. RESULTS: Endometrial thickness was greater in cycles resulting in pregnancy than in cycles not resulting in pregnancy (11.9 vs. 11.3 mm, respectively). Clinical pregnancy rates increased gradually from 53% among patients with a lining of <9 mm, to 77% among patients with a lining of > or =16 mm. Multiple logistic regression analysis indicated significant effects of age, embryo quality, and endometrial thickness on both clinical pregnancy rates and live-birth or ongoing pregnancy rates. There was also a marginally significant trend toward decreasing rates of spontaneous pregnancy loss with increasing endometrial thickness. CONCLUSIONS: Clinical pregnancy and live-birth or ongoing pregnancy rates increase significantly with increasing endometrial thickness, independent of the effects of patient age and embryo quality.
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