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  • Title: Use of methylene blue as a diagnostic aid in early detection of oral cancer and precancerous lesions.
    Author: Chen YW, Lin JS, Fong JH, Wang IK, Chou SJ, Wu CH, Lui MT, Chang CS, Kao SY.
    Journal: Br J Oral Maxillofac Surg; 2007 Oct; 45(7):590-1. PubMed ID: 17081665.
    Abstract:
    We assessed the sensitivity, specificity, and positive and negative predictive value of methylene blue staining in the diagnosis of oral cancer in 58 patients. The sensitivity was 90%, the specificity 69%, positive predictive value 74%, and negative predictive value 87%. Because of the number of false negatives and false positives we recommend that the diagnosis should always be confirmed by histopathological examination of a biopsy specimen. Methylene blue staining may, however, be useful as a screening tool for oral cancer in large, high-risk groups in a similar way to the more expensive toluidine blue.
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