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  • Title: Rapid systemic bone resorption during the course of Staphylococcus aureus-induced arthritis.
    Author: Verdrengh M, Carlsten H, Ohlsson C, Tarkowski A.
    Journal: J Infect Dis; 2006 Dec 01; 194(11):1597-600. PubMed ID: 17083046.
    Abstract:
    Bacterial arthritis is the most rapidly progressing destructive joint disease in humans. To evaluate bone resorption and formation, mice were injected with Staphylococcus aureus and killed after 3 and 14 days. Both total and trabecular bone mineral density were, compared with those in uninfected controls, already significantly reduced 3 days after bacterial inoculation. Serum levels of type I collagen fragments were significantly increased and osteocalcin levels decreased in mice infected with S. aureus, compared with those in noninfected mice, 3 and 14 days after bacterial inoculation. This study shows that there is a rapid and easily measurable systemic bone resorption during S. aureus-induced arthritis.
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