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  • Title: Effect of the folk remedy, Bainiku-ekisu, a concentrate of Prunus mume juice, on Helicobacter pylori infection in humans.
    Author: Nakajima S, Fujita K, Inoue Y, Nishio M, Seto Y.
    Journal: Helicobacter; 2006 Dec; 11(6):589-91. PubMed ID: 17083382.
    Abstract:
    BACKGROUND: Bainiku-ekisu, a concentrate of Japanese apricot (Prunus mume) juice, is a traditional Japanese folk remedy for treatment of dyspepsia since more than a thousand years ago. Fujita et al. previously reported in vitro antibacterial effect of Bainiku-ekisu to Helicobacter pylori. We conducted an in vivo pilot study to evaluate the possibility that Bainiku-ekisu may have an antibacterial effect on H. pylori in the human stomach. MATERIALS AND METHODS: Consecutive 18 H. pylori-positive subjects were included. Approximately 130 mL 1% Bainiku-ekisu solution was ingested by the subjects twice a day for 12 weeks. Urea breath test (UBT) was performed before ingestion, and 2 and 12 weeks after starting ingestion of Bainiku-ekisu, and UBT values were compared. RESULTS: Bainiku-ekisu therapy resulted in a slight fall in UBT values after 2 weeks (from 30.1 +/- 6 to 23.5 +/- 6 in ITT analysis, p = .094; from 31.2 +/- 6 to 24.7 +/- 6 in PP analysis, p = .124) (data are shown with mean +/- SE). In two instances (11%), the UBT values became negative. Fourteen subjects completed the trial for 12 weeks and there was no significant change in UBT values (from 30.1 +/- 6 to 25.9 +/- 6 in ITT analysis, p = .450; from 35.6 +/- 6 to 31.4 +/- 7 in PP analysis, p = .555). CONCLUSION: Our results are consistent with the antibacterial effect of Bainiku-ekisu on H. pylori in the human stomach. However, the bacteria were not successfully eradicated with 2- or 12-week ingestion of a Bainiku-ekisu solution. Subsequent studies will need to identify a clinically useful regimen.
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