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  • Title: Retinoic acid regulates, in vitro, the two normal pathways of differentiation of human laryngeal keratinocytes.
    Author: Mendelsohn MG, Dilorenzo TP, Abramson AL, Steinberg BM.
    Journal: In Vitro Cell Dev Biol; 1991 Feb; 27A(2):137-41. PubMed ID: 1708372.
    Abstract:
    We have investigated the regulation of the two normal differentiation pathways followed by laryngeal epithelium. Using a tissue culture system that permits growth of cells at the air-liquid interface in serum-free medium, we found that modulating the concentration of retinoic acid is sufficient to determine which pathway is used. At 10(-8) M retinoic acid, the cells form a stratified squamous epithelium which expresses the differentiation-specific keratin K13. At 10(-7) M retinoic acid, the cells form a ciliated pseudostratified epithelium, with no expression of K13. These results are distinct from those seen with foreskin keratinocytes, which have only a single pathway of normal differentiation.
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