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  • Title: Quality of life and depressive symptoms in patients with major depression and end-stage renal disease: a matched-pair study.
    Author: Berlim MT, Mattevi BS, Duarte AP, Thomé FS, Barros EJ, Fleck MP.
    Journal: J Psychosom Res; 2006 Nov; 61(5):731-4. PubMed ID: 17084154.
    Abstract:
    OBJECTIVE: To compare the quality of life (QOL) and depressive symptoms of outpatients with major depression with that of nondepressed individuals undergoing hemodialysis (matched for age, gender, and ethnicity). METHODS: We used the WHOQOL BREF and the Beck Depression Inventory (BDI). RESULTS: After univariate analyses, depressed patients' QOL scores were significantly lower (P<.0001) in all the assessed domains (i.e., physical health, psychological, social relationships, environmental, and global QOL). Additionally, there was a significant difference in the severity of depression among the study groups (P<.0001). Finally, after multiple regression analysis, the QOL profile of depressed subjects remained significantly worse even when controlling for depression scores and diagnostic status. CONCLUSION: The subjective QOL of patients with major depression is significantly lower than that of subjects undergoing hemodialysis.
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