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  • Title: ERK1/2 MAP kinases in cell survival and apoptosis.
    Author: Lu Z, Xu S.
    Journal: IUBMB Life; 2006 Nov; 58(11):621-31. PubMed ID: 17085381.
    Abstract:
    ERK1/2 is an important subfamily of mitogen-activated protein kinases that control a broad range of cellular activities and physiological processes. ERK1/2 can be activated transiently or persistently by MEK1/2 and upstream MAP3Ks in conjunction with regulation and involvement of scaffolding proteins and phosphatases. Activation of ERK1/2 generally promotes cell survival; but under certain conditions, ERK1/2 can have pro-apoptotic functions.
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