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  • Title: [Centroblast morphology: a morphometric evaluation by means of computer-aided image analysis].
    Author: Bergmann M, Harms H, Albert R, Droese M, Müller-Hermelink HK.
    Journal: Verh Dtsch Ges Pathol; 1990; 74():211-5. PubMed ID: 1708586.
    Abstract:
    In cytologic preparations, cell images from 30 cases of high grade malignant Non-Hodgkin's lymphoma (NHL) and 10 cases of tonsillitis have been analysed using a colour TV microscope system, high resolution scanning and image processing. Multivariate analysis of 30 cell features allowed satisfying recognition and discrimination of centrocytes, centrocyte-like centroblasts, ordinary centroblasts and multilobated centroblasts. In addition, according to their image analytical data, the ordinary centroblasts from NHL formed 5, and those from tonsillitis 4 well defined, homogeneous clusters. Even at simultaneous analysis, there was an essential overlap only between centroblast subtype 3 from NHL and subtype 9 from tonsillitis, but reliable discrimination of all the rest.
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