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  • Title: [Immunophenotypic and genotypic characterization of T-cell populations in thymomas].
    Author: Scherrer CC, Knecht H, Wiesli M, Dirsch OR, Odermatt B, Heitz PU.
    Journal: Verh Dtsch Ges Pathol; 1990; 74():350-3. PubMed ID: 1708611.
    Abstract:
    The T cell component of eight thymomas has been studied by immunohistochemistry and Southern blot analysis. In the cortical areas of thymomas the T cells expressed an immature cortical phenotype. In cortical and medullary areas T cell Receptor (TcR) alpha-beta lymphocytes heavily predominated over TcR gamma-delta lymphocytes. No genomic rearrangement of TcR and Immunoglobulin genes could be detected, thus supporting the non neoplastic nature of the lymphocyte component in thymomas.
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