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Title: [Exacerbation of tonicoclonic seizures in a juvenile myoclonic epileptic taking lamotrigine]. Author: Maiga Y, Nogues B, Guillon B. Journal: Rev Neurol (Paris); 2006 Nov; 162(11):1125-7. PubMed ID: 17086150. Abstract: INTRODUCTION: Lamotrigine is an anti-epileptic drug considered as a first-line therapy in idiopathic generalised epilepsy. Lamotrigine is well-tolerated and secondary aggravation of epileptic syndromes has rarely been reported. CASE REPORT: We report the case of a 19 year-old man with juvenile myoclonic epilepsy in whom lamotrigine lead to the exacerbation of generalised tonico-clonic seizures, reversible when lamotrigine was stopped and substituted by valproic acid. CONCLUSION: Lamotrogine may induce exacerbation of generalised tonico-clonic seizures and myoclonic jerks in juvenile myoclonic epilepsy.[Abstract] [Full Text] [Related] [New Search]