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  • Title: [Antiplatelet therapy after aspirin-induced upper gastrointestinal bleeding].
    Author: Johansen M.
    Journal: Tidsskr Nor Laegeforen; 2006 Nov 02; 126(21):2802-4. PubMed ID: 17086221.
    Abstract:
    It is common practice to replace aspirin with clopidogrel in patients with gastrointestinal intolerance to aspirin. Recent studies suggest that a combination of aspirin and a proton pump inhibitor is a better alternative for these patients. The CAPRIE and CURE studies have not shown any clinically relevant difference in effect between aspirin and clopidogrel. The incidence of bleeding is also similar when aspirin is used in doses < 160 mg. A recent study by Chan et al. concluded that a combination of aspirin and esomeprazole is superior to clopidogrel in the prevention of recurrent gastrointestinal bleeding. Using aspirin and a proton pump inhibitor is also the least expensive alternative.
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