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  • Title: [Inhibitory effect of weikangfu recipe on growth of mouse S180 tumor and its apoptotic induction].
    Author: Nie XH, Shi BJ, Tao WY.
    Journal: Zhongguo Zhong Yao Za Zhi; 2006 Sep; 31(17):1457-60. PubMed ID: 17087091.
    Abstract:
    OBJECTIVE: To study the growth inhibition of Weikangfu recipe on S180 tumor and its apoptotic induction. METHOD: S180-bearing mice were orally administrated with different dosages of Weikangfu recipe, and the growth inhibition was evaluated; apoptotic cells induced were detected by flow cytometry and DNA agarose gel electrophoresis. RESULT: Weikangfu recipe showed significant inhibition on the growth of S180 tumor in a dose-dependent manner, compared with the control group. From apoptotic analyses, Weikangfu recipe induced a dose-dependent apoptosis of S180 tumor cells and arrested the cell cycle distribution at G0-G1 phase. At the same time, the up-regulation of p53 and bax and down-regulation of bcl-2 were observed in S180 tumor cells of the treated groups. CONCLUSION: Our findings demonstrate that Weikangfu recipe can significantly inhibit the growth of S180 tumor and induce apoptosis through expression alteration of p53, bax and bcl-2.
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