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  • Title: [Case of rapid progressive interstitial pneumonia associated with primary Sjogren syndrome].
    Author: Naruse Y, Inui N, Yasui H, Karayama M, Yamazaki S, Muramatsu E, Uto T, Morita S, Tsuchiya T, Nakano Y, Enomoto N, Imokawa S, Suda T, Chida K.
    Journal: Nihon Kokyuki Gakkai Zasshi; 2006 Oct; 44(10):721-6. PubMed ID: 17087339.
    Abstract:
    A 72-year-old woman with a dry cough and dyspnea on exertion was admitted to our hospital. A chest radiograph showed reticular opacities and volume loss in both lower lung fields. She was troubled with xerostomia and her laboratory test showed positive reaction for anti SS-A and SS-B antibody. Labial biopsy led to a diagnosis of primary Sjogren's syndrome (pSjS). Lung biopsy specimens obtained by video-assisted thoracoscopic surgery (VATS) revealed interstitial pneumonia. On the sixth postoperative day, hypoxemia acutely worsened and her chest radiograph showed widespread diffuse ground-glass attenuation. A diagnosis of acute exacerbation was made, and steroid and immunosuppressive therapy was started. In spite of intensive therapy, she died due to respiratory failure. We report a rare case of interstitial pneumonia with pSjS resulting in acute exacerbation.
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