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  • Title: Eosinophilic esophagitis: pathogenesis, genetics, and therapy.
    Author: Blanchard C, Wang N, Rothenberg ME.
    Journal: J Allergy Clin Immunol; 2006 Nov; 118(5):1054-9. PubMed ID: 17088129.
    Abstract:
    Eosinophilic esophagitis (EE) is a recently recognized disorder characterized by the accumulation of eosinophils in the esophagus. Symptoms of EE frequently mimic those of gastroesophageal reflux disease, but the 2 diseases are quite distinct in terms of the histopathology and response to therapy. We demonstrate that EE involves the interplay of numerous genes, especially the eosinophil chemoattractant eotaxin-3, allowing molecular distinction from other forms of esophagitis and consideration of targeted therapeutic intervention.
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