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  • Title: Hepatitis C virus (HCV) NS5B nonnucleoside inhibitors specifically block single-stranded viral RNA synthesis catalyzed by HCV replication complexes in vitro.
    Author: Yang W, Sun Y, Phadke A, Deshpande M, Huang M.
    Journal: Antimicrob Agents Chemother; 2007 Jan; 51(1):338-42. PubMed ID: 17088480.
    Abstract:
    Replication complexes of hepatitis C virus synthesized two major species of viral RNA in vitro, double stranded and single stranded. NS5B nonnucleoside inhibitors inhibited dose dependently the synthesis of single-stranded RNA but not double-stranded RNA. Moreover, replication complexes carrying a mutation resistant to a nonnucleoside inhibitor lost their susceptibilities to the inhibitor.
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