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  • Title: Granulocyte colony-stimulating factor corrects the neutropenia associated with glycogen storage disease type Ib.
    Author: Wang WC, Crist WM, Ihle JN, Arnold BA, Keating JP.
    Journal: Leukemia; 1991 Apr; 5(4):347-9. PubMed ID: 1709246.
    Abstract:
    A young woman with glycogen storage disease, type Ib, and chronic neutropenia had severe recurrent infections. In a life-threatening situation, treatment with granulocyte colony-stimulating factor (G-CSF) resulted in the prompt correction of neutropenia. Subsequently, daily G-CSF therapy has allowed the maintenance of a normal neutrophil count and marked clinical improvement over a period of 18 months. The spectrum of neutropenic conditions which are responsive to G-CSF should include this inherited metabolic disorder.
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