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  • Title: Parallel solution-phase synthesis of acrylonitrile scaffolds carrying L-alpha-amino acidic or D-glycosyl residues.
    Author: Fioravanti S, Pellacani L, Tardella PA, Morreale A, Del Signore G.
    Journal: J Comb Chem; 2006; 8(6):808-11. PubMed ID: 17096568.
    Abstract:
    A practical and straightforward protocol for the preparation of a solution-phase library of acrylonitrile scaffolds is reported. Target compounds were obtained in high yield, stereoselectivity, and purity by two simple and practical steps from cyanoacetic acid. Moreover, our study proposes a synthetic approach starting from the constructed library to obtain three-membered heterocycles.
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