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  • Title: Antibody persistence and immune memory elicited by combined hepatitis A and B vaccination in older adults.
    Author: Höhler T, Groeger-Bicanic G, Hoet B, Stoffel M.
    Journal: Vaccine; 2007 Feb 09; 25(8):1503-8. PubMed ID: 17097774.
    Abstract:
    Response to hepatitis A and B vaccines has been reported to decline with age. This open, prospective, single-site study examined the long-term response to the combined hepatitis A/B vaccine Twinrix in 98 primary responders aged 45-67 years. Levels of antibody against hepatitis A virus (HAV) and hepatitis B surface antigen (HBs) were tested 30 months after initial vaccination. At this stage, all participants remained seropositive for anti-HAV and 70% for anti-HBs. A booster vaccination was offered to those who had responded to the first vaccination but then lost protective levels of anti-HBs. An anamnestic response was observed in all cases.
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