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  • Title: Central nervous system graft-versus-host disease: report of two cases and literature review.
    Author: Kamble RT, Chang CC, Sanchez S, Carrum G.
    Journal: Bone Marrow Transplant; 2007 Jan; 39(1):49-52. PubMed ID: 17099715.
    Abstract:
    Two patients with a plausible diagnosis of central nervous system graft-versus-host disease (CNS-GVHD) are described. Both presented with neurological manifestations 6 and 18 months following allogeneic transplant with hemiparesis, seizure, encephalopathy and magnetic resonance findings of hyperintense white matter lesions on T-2 weighed images. Brain biopsy in one and autopsy in the other revealed profound perivascular lymphocytic infiltrates composed predominantly of T-lymphocytes that were of donor origin. Although an unequivocal diagnosis of CNS-GVHD is difficult to establish, the transplantation community should be aware of this controversial entity.
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