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  • Title: Myelodysplastic syndrome with an unbalanced 1;16 translocation in a case of early age of onset.
    Author: Dean S, Mohamed AN.
    Journal: Am J Hematol; 2007 May; 82(5):396-9. PubMed ID: 17099874.
    Abstract:
    We present a 30-year-old male patient diagnosed with myelodysplastic syndrome (MDS). Chromosome analysis of the bone marrow aspirate revealed a derivative chromosome resulting from an unbalanced 1;16 translocation causing the gain of 1q and loss of 16q. Dual color fluorescence in situ hybridization demonstrated that the 1q;16p derivative chromosome contained centromeric material derived from chromosome 1, and accordingly the translocation was designated as a der (1)t(1;16)(p11;p11.1). Review of literature revealed that 1;16 translocation in MDS is nonrandom and is always described as unbalanced, resulting in trisomy 1q and monosomy 16q.
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