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  • Title: Heterodimeric capping proteins constitute a highly conserved group of actin-binding proteins.
    Author: Hartmann H, Schleicher M, Noegel AA.
    Journal: Dev Genet; 1990; 11(5-6):369-76. PubMed ID: 1710551.
    Abstract:
    The two subunits of the heterodimeric protein cap32/34, an actin-binding protein, are encoded by separate single-copy genes. We have established the genomic structure of both genes. A sequence comparison of cap32/34 with capZ from chicken skeletal muscle and two partially known sequences from Saccharomyces cerevisiae and Xenopus laevis show that heterodimeric capping proteins belong to a highly conserved group of actin-binding proteins. This conclusion is supported by the cross-reaction of polyclonal antibodies against cap32 and cap34 with proteins from lower and higher eukaryotes. In addition, a system is presented that allows the expression of truncated cap34 polypeptides under the control of the cap34 promoter.
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