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  • Title: Mixed connective tissue disease associated with MPO-ANCA-positive polyangiitis.
    Author: Kitaura K, Miyagawa T, Asano K, Oouchi S, Miki T, Fujisawa T, Ishida K.
    Journal: Intern Med; 2006; 45(20):1177-82. PubMed ID: 17106166.
    Abstract:
    The patient was a 42-year-old woman diagnosed as having MCTD and Sjögren's syndrome in 1989, and who was taking oral prednisolone. Proteinuria and microscopic hematuria were pointed out for the first time in December 2004. She was referred to our hospital because of massive hemoptysis. Advanced renal failure, anemia and pulmonary alveolar hemorrhage were diagnosed on admission. She was positive for serum MPO-ANCA. The patient was started on a therapy that included steroids, cyclophosphamide and plasmapheresis. However, her respiratory condition was untreatable and she died on the 16th day of hospitalization. The autopsy revealed alveolar hemorrhage in the lungs and crescentic glomerulonephritis. This patient was considered as a rare case of MCTD associated with MPO-ANCA-positive microscopic polyangiitis.
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