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  • Title: Hybridization of DNA to bead-immobilized probes confined within a microfluidic channel.
    Author: Kim J, Heo J, Crooks RM.
    Journal: Langmuir; 2006 Nov 21; 22(24):10130-4. PubMed ID: 17107010.
    Abstract:
    We report the factors influencing the capture of DNA by DNA-modified microbeads confined within a microfluidic channel. Quantitative correlation of target capture efficiency to probe surface concentration, solution flow rate, and target concentration are discussed. The results indicate that the microfluidic system exhibits a limit of detection of approximately 10(-10) M (approximately 10(-16) mol) DNA and a selectivity factor of approximately 8 x 10(3). Typical hybridization times are on the order of minutes.
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