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  • Title: The role of reactive oxygen species and oxidative stress in mediating particulate matter injury.
    Author: Xia T, Kovochich M, Nel A.
    Journal: Clin Occup Environ Med; 2006; 5(4):817-36. PubMed ID: 17110294.
    Abstract:
    Numerous reports link oxidative stress to particulate matter (PM)-induced adverse health effects. Increasing evidence is being collected that reactive oxygen species and oxidative stress are involved in PM-mediated injury. The physical characteristics and the chemical composition of PM play a key role in reactive oxygen species generation in vitro and in vivo. According to the hierarchical oxidative stress hypothesis, antioxidant phase II enzymes protect against PM-induced inflammation and cytotoxicity. This concept is useful in understanding PM-induced disease models, susceptibility, and biomaker development to access exposures outcomes and is useful for developing therapeutic intervention in PM-induced adverse health effects.
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